Into the Immortal Cultivation - Chapter 1880

[Chapter 40]

In the history of the universe without spiritual energy, the discovery process of prions was extremely tortuous.

In fact, the first researched disease [human prion disease] that uses prions as pathogens and can infect people was discovered as early as 1955. At that time, an American explorer and doctor named Gaidacek discovered the disease while investigating a primitive tribe with cannibalistic practices in the eastern highlands of Papua-New Guinea.

The American doctor has even concluded that the disease, called “kuru disease”, was caused by the cannibal tribe eating the brains of dead relatives.

He used chimpanzees as experimental animals, diluted the brain tissue homogenate obtained after the death of kuru patients, and injected them into chimpanzees.

After that, he successively used physical means to separate larger bacteria and parasites, and killed nucleic acids through ultraviolet light to determine the pathogen of Kuru.

He even tried treating these homogenates with proteolytic enzymes.

Of course, proteolytic enzymes completely incapacitate these homogenates of pathogenicity.

However, his first reaction was… Well, it must be the protease that destroyed the shell of the “Kuru disease virus”.

This should be a new virus.

At the time, this kind of thinking was quite natural, or rather, almost all scholars would.

And when Gedacek discovered Kuru and made an inaccurate…no, it could even be said to be a “wrong” conclusion, the future discoverer of prions, Pruzina, was just in middle school.

This achievement earned Gaidasek the Nobel Prize in Physiology and Medicine in 1976.

As a child, Prusiner was still pondering whether to use hamsters with an incubation period of only 100 days instead of mice with an incubation period of 200 days.

In addition, by the way, the earliest human prion disease that can infect humans was discovered in 1913 by two German physicians, Hans Cruzfeld and Alphonse Jacob.

And Pruziner also chose to study scrapie, which has similar symptoms to CJD and mad cow disease, after witnessing that one of his patients was tortured to death by Creutzfeldt-Jakob disease in 1972.

Between 1913 and 1997, Earth scholars still had many chances to conclude that “prions are special pathogens.”

However, Prusiner’s views were not accepted by others until the 1996 accidental outbreak of mad cow disease caused by the large-scale use of dead beef bone meal in the UK.

In fact, after 1997, the attitude of the entire academic community to Prusiner was only “reluctant acceptance”.

Even in 2001, a major result of prion research was published in the journal and stated that “the result will strongly support Prusiner’s hypothesis that Prusiner won the Nobel Prize in 1997 for this hypothesis. prize”.

On June 14, 2001, a message was published in the journal Nature. Serono announced that a research group at its Serono Institute for Pharmacy, centered on Dr. Claudio Soto, has developed a detection technology for abnormal prion proteins.

To be precise, it reproduces the replication process of prions.

Protein Misfolding Cyclic Amplification Technology, referred to as pmca.

Song Shufu will never know how many difficulties he has overcome because of his poverty.

Song Shufu has spent ten years of research on his own, and if it is the accumulation of eight years of Prusina on Earth. With Song Shufu’s foundation, Ai Qinglan was able to complete this research in a short period of time.

And now, with Song Shufu’s last bit of luck, Ai Qinglan made a powerful leap.

If not for this unexpected discovery, then at least in the next few decades, Ai Qinglan will need to continue to work for this “hypothesis”.

Of course, “saving decades of effort” does not mean that decades of problems are solved in an instant.

In fact, this does not mean “end”. There are still many questions before Ai Qinglan.

Of course, compared to her counterparts on Earth, Ai Qinglan was undoubtedly much luckier.

Regarding the mechanism of prions, the most optimistic about the earth academic circles is the version proposed by Prusina in 1995. And Claudio Soto completed the pmca technology based on Prusina’s conjecture, following the idea of pcr.

Ai Qinglan directly discovered such a strange phenomenon, and she could directly infer the “principle” from the phenomenon.

“Why is this happening?” Ai Qinglan said in a low voice.

“Water flows down” because of “gravity”, “gravity” exists because of “universal gravitation”, and the source of gravity is “the curvature of space-time caused by mass”. The source of “quality” is the next thing to study.

No “phenomenon” is taken for granted. Even if it does seem so for granted.

Underneath “of course” lies the “Tao”.

Ai Qinglan wanted to think about why the source of pathogenic creatures could be amplified after ultrasonic treatment?

Why is it done in a reverse transcription polymerase chain reaction water bath?

After ultrasonic treatment, what kind of changes have occurred in the source of pathogenic creatures?

What kind of process does the normal life essence go through to be transformed into the pathogenic life essence?

Why does this process require no enzyme catalysis?

What is the mechanism of action of the source of pathogenic creatures…

and is it considered a “living creature” in the conventional sense?

All of this is a problem.

“The proof needs to be reset.” Ai Qinglan said, quickly writing on her notebook.

Evidence for repeating that operation at different temperatures.

Demonstration on repeating that operation under different intensity sonication.

Evidence for repeating that operation under sonication of different durations.

Evidence for repeating that operation using different numbers of pathogenic esophagus templates.

Evidence for repeating that operation after changing the buffer composition.

Regarding… There

are so many proofs that can be thought of in an instant, and countless inspirations are stirring in Ai Qinglan’s mind at the same time.

It can be seen that for a long period of time, this Demonstration Department… No, it may not be the only Demonstration Department. Ai Qinglan’s energy is enough to influence many Demonstration Departments. And if the Helix Shuangzun can recognize him, then some of the Jiyin Valley’s empirical department will do relevant verification. In short, for quite a long time, relevant evidence will not stop.

However, the development of the misfolding and cyclic amplification technology of life essence means that the results that used to take months to obtain can now be obtained in just a few hours.

This is simply a first-class magical method!

Just when Ai Qinglan was excited to demonstrate the design, Chen Feng came up and said to her: “Sister Lan, I know you are very happy, but now we have other procedures to run…”

… …………………………………………………………

The outer door notification system is a special system newly implemented by Shenzhou.

The core content of this system is only one point. When a cultivator has made a subversive achievement, he has the responsibility to notify the leaders of other sects of the immortal alliance first.

A few years ago, the large-scale incident of Wanfamen’s “incompleteness” caused by “incompleteness” is still vivid in my mind. Many skills of the Immortal League are close to being suspended for a while, and many high-level cultivators are unstable, and even their life safety cannot be guaranteed.

This is also the result of the preparations made in advance by many Wanfa cultivators, including Feng Luoyi, the national player of the common people, and the real Turing.

In recent years, a new generation of monks has gradually risen, subverting the past much faster than before. The most typical of them is Wang Qi, but other monks such as Mi Tianzhao also have such signs.

There are even old people who suspect that these younger generation of monks will directly play the dead race before powerful foreign enemies attack.

Therefore, after the large-scale incident of Wanfamen’s misfortune, Xianmeng also established a system of notification from the outer sect in addition to the similar peer review system.

If you have made a subversive achievement, you should inform the senior management of other sects first.

In this regard, Feng Luoyi was somewhat unhappy.

Because in most cases, this “senior in other fields” is probably him.

However, the direct cause of this system is his own apprentice, so he has to consider whether it is suitable or not to take this responsibility.

And now, his brain hurts even more.

Because, the report he received this time was that “this discovery is equivalent to shaking the position of evolution theory in the way of life.”

What is the status of evolution theory? For some practitioners of today’s law, they have almost risen to the level of faith.

Although the theory of natural evolution has undergone many revisions after the theories of heredity and blood roots were put forward, these revisions are only to make it precise and accurate, rather than “shaking” it.

If it was someone else who wrote this, it would be fine, because since the emergence of this “outer door notification system”, the Immortal Alliance has always received three or five reports of overthrow of the Way of Contrast from the disciples of the Immortal Court and even those from the side door.

However, adding the name “Ai Qinglan” to this report is different.

To put it this way, if other people came over and said that they wanted to overthrow the logic of arithmetic, Feng Luoyi would just laugh it off, but Wang Qi said that, Feng Luoyi would kill this traitor with one sword.

He has to pay attention to it, otherwise, Tianlingling will directly suffer catastrophe.

It’s just that when he really listened to Chen Feng’s narration, he had a kind of… um, how should I put it, it was the feeling of “it’s just that”.

In this way, it can be regarded as “equal to the theory of shaking the sky”?

Although every empirical department has the element of nonsense and asking for money, is it a little too much for you to play like this? Do you want to be so exaggerated?

How can it be so small that it can’t replicate itself?

Chen Feng was a little anxious. He really didn’t quite know how to describe the significance of this discovery.

Ai Qinglan on the side opened her eyes: “Senior Feng, please let me explain the follow-up.

”

[End of this Chapter]